皮膚厚み測定を用いたツベルクリン反応強度比較の研究
スポンサーリンク
概要
- 論文の詳細を見る
The pathological nature of tuberculin reaction consists primarily of the swelling of the intracutaneous collagenous fibers and cell infiltration. In measuring, however, extreme individual differences measuring quantity of induration prohibited this measurement for practical usage. To lessen the measurement errors, a simple method of measuring the pinched skin thickness in the tuberculin reacted part was reported by Dr. Chiba and Dr. Fukuda and was put into practical use. The report was accomplished by comparing the intensity of tuberculin reaction according to this method, besides the conventional one, and the following groups of National Railways Employees were examined in the annual physical examination. 1) The distribution curve of the pinched skin thickness (in the injected part) was found to be monophasic with the peak at 3 or 4 mm. 2) The percentage of over 5 mm thickness of the total examinees were found to be the index of intensity of reaction which could be applied for practical usage. 3) In observing the age factor of all the tuberculin positives, intensity of reaction was stronger with the increasing of age. Its peak was between 45 and 49 years of age. Those over that age showed weakening of intensity. The tendency was the same among those with and without lesions. So it can be said that there is an intensified tendency of a non-specific reaction with the increasing of age. 4) In observing those with lesion, in each lesion type, in two age-groups below 29 and above 30 years of age, the following trend of intensifying was observed : Calcified lesion ≒ circumscribed cirrhotic lesion > infiltrative lesion > mixed lesion, healed or minute lesion > unhealed and advanced lesion. Thus the healed lesion (or small lesion) shows a tendency to have a stronger reaction than the unhealed (large) lesion. 5) Among the infected whose radiograph showed no findings, weaker reaction was seen in those with former history of BCG inoculation than those without. BCG inoculation seemed to prevent the bacilli infected area from spreading and thus allergic reactions from intensifying. 6) In observing the degree and the work environment in persons with and without findings after tuberculous infection, those under light work degree (indoor works) were found to have a stronger reaction. Those under middle and heavy work degree (outdoor work) were found to have weaker reaction. Tuberculin reaction of each group paralleled the rate of chest findings.
- 千葉大学の論文