ジギコリン・セジラニツドの臨床的効果の比較研究
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概要
- 論文の詳細を見る
So-called single digitalizing dose of 6.0mg for Digicorin introduced by Prof. S. Saitoh and his collaborators is certainly an important factor in popularizing Digicorin; however it is somewhat dangerous to repose the over-confidence that all patients could be managed alike. The results of fractional saturation are, as a rule, rather satisfactory; each fractionated dose being administered at intervals of about 4-6 hours with Digicorin or Cedilanid until the desired therapeutic effect can be gained. The toxicity ofrecently manufactured pure preparates of digitalis can occur as easily as that of digitalis powdered leaf. Essentially the range between therapeutic and toxic dose of digitalis is quite narrow, except for both Digicorin and Cedilanid with relatively wide distance. The dosage of either Digicorin or Cedilanid, like that of other glycosides varies from patient to patient (Tbl. 19, 20). The maintenance dose of 2.0mg as to Digicorin has been found too high for most patients despite of its rapid dissapation; thus a fairly high incidence of intoxication has been observed when such a dose is continued for more than a few weeks. While 1.0mg of Cedilanid pro die administered orally shows therapeutical effect among 50% of cases, it becomes minimal-toxic among 13% of them. In turn while 1.75mg of Cedilanid pro die becomes minimal-toxic among 50% of cases, it is therapeutically effective among 84% of them. The maintenance dose of Digicorin pro die among 50% of cases administered intravenously can be calculated as 0.8(1951), 1.6(1952), 1.7(1953) and 1.7mg(1955) respectively, whereas it shows minimal toxicity on 15(1951), 20(1952), 10(1953) and 10%(1955) among total patients. And, the minimal toxic dose among 50% of cases can be calculated as 1.6(1951), 2.3(1952), 2.45(1953) and 2.8mg(1955) respectively, whereas it shows therapeutic effect on 82(1951), 82(1952), 84(1953) and 90%(1955) among total patients. The toxicity of glycosides with rapid dissapation rate such as Digicorin and Cedilanid is apt to be overlooked in clinical praxis because of considerably short duration, although the toxicity of a long acting glycoside with slow rate of dissapation much as a digitoxin may be produced on what is thought to be still the maintenance dose. In cardiac failure for which the restriction of salt intake and the increasing use of mercurial diuretics are necessary, it becomes often difficult to assay a proper therapeutic dosage of glycosides. In clinical praxis, in such cases what actually is obtained is confined to estimate only the maximal tolerance of digitalis. In such patients the toxicity is often manifested by cardiac arrhythmias.
- 千葉大学の論文
- 1957-03-28