急性肺水腫の実験的ならびに臨床的研究 : 気管枝喘息ならびに急性肺水腫の臨床的ならびに実験的研究(第2編)
スポンサーリンク
概要
- 論文の詳細を見る
The pathogenic factors of the acute pulmonary edema, above all, its neurogenic participation were investigated and following results were obtained: 1. The frequency of the finding of pulmonary edema was observed in 230 autopsies examined in the pathological department of Chiba University. The pulmonary edema was recognized, more or less, in all 13 cases with central nervous diseases. 21 patients with pulmonary edema were found in 217 cases without central nervous disorders. Those results were defined to disclose the possible role of neurogenic factors, especially of central nervous system, initiated by von Cyon. However the decisive conclusion can not be drawn, unless other complicating facts, for example, cardiac vascular and pulmonary lesions, course of disorders until death etc. are examined. 2. The pulmonary edema which is caused by the intravenous injection of massive epinephrine into rabbits can be suppressed by the premedication with adrenolyticum, for instance, Yohimbine. Pendiomide, one of ganglionic blocking agents, also inhibits the epinephrine pulmonary edema though the inhibitory action is somewhat less than that of Yohimbine. It is said by some authorities that Epinephrine increases the blood histamine content, yet, as far as dosages used in my experiments are concerned, the suppression can be hardly recognized in the medication of Pyribenzamine, an antihistamica. In the experiment observed in dogs, it was found that Yohimbine extinguishes not only the abrupt elevation of arterial blood pressure, but also the arrhythmia occurring at the second stage of massive epinephrine injection. The pharmacodynamic tendency similar to Yohimbine is recognized in action modes of Regitine and Priscol. 3. An acute pulmonary edema can arise in mouse receiving large dose of Insuline intravenously. But it may be still risky to say that the incidence of "Insuline" pulmonary edema is possible to establish, because the marked salivation and bronchorrhea occur at that juncture.Some mice remain dyspneic for some time after the cessation of hypoglycemia; and there can be found also evidences of prominent water retension and striking increase in extracellular fluid volume which diuretic drugs quickly ameliorate. In addition, it must be borne in mind that the hypoglycemia causes increased production of endogenous epinephrine. In order to clarify this point, Yohimbine, Pendiomide were injected and it is ascertained that they can inhibit the occurrence of acute pulmonary edema with large dose ofInsuline while Pyribenzamine lacks this action. 4. An acute pulmonary edema is induced in guinea pigs applied with NH_4Cl orally. This pulmonary edema can be ameliorate with the use of Yohimbine, Pendiomide, but can not be with Pyribenzamine. 5. An acute pulmonary edema develops in the mice into which ANTU is injected intraperitoneally. Histological examinations of lung following after the injection revealed that this acute pulmonary edema begins with dilatation of pulmonary hilar lymphatics. The augmentation of the permeability of pulmonary capillaries and the overactivity of pulmonary lymphatic system are thought to be the most important cause of this acute pulmonary edema. 6. An acute pulmonary edema can arise in 'dogs and rabbits which are infused with physiological NaCl solution excessively. Suce an acute pulmonary edema is facilitated to develop by the denervation of pressoreceptoric area.
- 千葉大学の論文
- 1957-01-28
著者
関連論文
- 10. 低酸素状態の循環分析(続報)(第337回千葉医学会例会(臨床))
- 急性肺水腫の実験的ならびに臨床的研究 : 気管枝喘息ならびに急性肺水腫の臨床的ならびに実験的研究(第2編)
- 気管枝喘息の血液相 : 気管枝喘息ならびに急性肺水腫の臨床的ならびに実験的研究(第1編)