蛔虫感染と栄養との関係についての実験的研究
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概要
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That the resistance or sensitivity of the living organism to Ascaris infection is influenced greatly by the quality of foods has been proved by many researchers. For the purpose of evaluating the effects of various nutritive factors on Ascaris infection, the author conducted experiments in which ripe Ascaris eggs isolated from the hog were given to the following seven groups of mice to which different varieties of foods had been administered: The Group 1 (fed on a diet in which meat extract containing large amounts of animal crude protein is added); the Group 2 (fed on a diet in which casein is added); the Group 3 (fed on a diet very rich in vitamin A); the Group 4 (fed on a diet having very high vitamin B complex ratio; the Group 5 (fed on a diet very rich in vitamin C); the Group 6 (fed on a diet deficient in nutritive value); and the Control Group (fed on the base foods consisting of 3.0g flour, 1.5g water and 3.0g fresh vegetables per 10.0g of body weight). The quantity of meat extract added to the base foods was gradually increased starting at 0.015g. Casein contained in the diet fed to the Group 2 was equal in amount to 18 per cent of the base foods. The diet fed to the Group 3 consisted of the base foods plus vitamin A 300 I.U. dissoluble in water. The diet administered to the Group 4 contained 0.025mg vitamin B_i 0.5mg vitamin B_2, 0.01mg vitamin B_6, and 0.05γ vitamin B_<12> in addition to the base foods. The Group 5 was fed on the diet containing 1.0mg vitamin C in addition to the base foods. The group 6 was fed on the base foods for 1 week, after which flour in the diet was gradually replaced by polished rice powder and the quantity of foods was reduced. In the average rate of increase of body weight, the Groups 1 and 2 were higher and the Groups 4 and 5 were slightly higher than the Control Group, while the Group 3 was slightly lower than the Control Group. The mice were killed every 24 hours under either anesthesia for 6 days from 72 hours to 192 hours after being infected with Ascaris larvae.Then the liver and the lung removed from the mice were examined for Ascaris larvae that might have migrated there. The results of the observations showed that the numbers of Ascaris larvae found in the liver andlung. were markedly lower from the third to the sixth day and from the third to the eighth day, respectively, in the Group 1 than in the Control Group; they were considerably lower, in both the liver and the lungs (from the third to the eighth day), in the Group 2 than in the Control Group; they were markedly lower, in both the liver and the Bungs; in the Groups 3 and 4 than in the Control Group; they were markedly higher in the Group 5 than in the Control Group; and they were lower in the Group 6 than in the Control Group. The results of the present experiments would show that the diet rich in protein, vitamin A or vitamin B complex might increase resistance to Ascaris infection, while the diet too rich in vitamin C might rather promote its infection. The low rate of Ascaris infection in undernourished mice would be a problem requiring further investigations.