動脈性衝撃注射療法の知見補遺 : 特に各種薬液注入による人白血球墨粒貧喰度に及ぼす影響に就いて
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概要
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It is a well-known fact that the arterial injection therapy developed in 1942 by the late Prof. Seo and Prof. Nakayama is markedly effective in the treatment of various diseases, especially inflammatory or rheumatic ones. The drug that has been used for the purpose of this therapy is the hypertonic solution of dextrose or the solution of dextrose to which is added certain drug assumed to be most suitable for the particular disease. It is because the researches carried out so far have revealed that the hypretonic solution of dextrose is most effective that it has been and is still used for the purpose of this therapy. There is no reason why no drugs, if they prove more effective, should not be used. If such drugs could be found, they would, as a matter of course, take the place of the hypertonic solution of dextrose. With this view in mind, the author, under instructions of Prof. Nakayama, conducted a series of experiments in which solutions of various kinds of drugs were tested for their effects on the phagocytic activity of carbon particles in the leukocyte for the purpose of evaluating availability of these drugs for arterial injections. The results of the experiments are . summarized as follows: 1) The temperature of the solutions of drugs used for arterial injections exerted no appreciable influence on the phagocytic activity of carbon particles in the leukocyte. 2) There was no uniform relation between the osmotic pressure of the solutions of drugs injected and the phagocytic activity of carbon particles in the leukocyte; the hypertonic solution of a drug did not necessarily exert more favorable influence than the isotonic solution. 3) The solution of a drug injected exerted favorable influenceon the phagocytic activity of carbon particles in the leukocyte when its pH signified weak acidity; it exerted unfavorable influence when its pH indicated weak alkalinity. 4) The solution of a drug injected exerted favorable influence on the phagocytic activity of carbon particles in the leukocyte when the salt contained was Cacl_2 or Kcl; it exerted no appreciable influence when it was Mgcl or Nacl. 5) Among the various drugs mixed with 0.9 per cent physiological salt solution and used for arterial injections, adrenaline chloride, moxsol and ecron exerted highly favorable influence on the phagocytic activity of carbon particles in the . leukocyte. 6) Fructose, which, like dextrose, is a hexose, exerted as favorable an influence on the phagocytic activity of carbon particles in the leukocyte as dextrose. 7) It would be the action of dextrose that render arterial injections markedly effective. 8) Among the drugs tested in the present investigations, no drugs were proved more suitable for use in arterial injections than dextrose.
- 千葉大学の論文
- 1956-05-28
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