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Since Eppinger u. Hess first performed investigations on the functioning of the autonomic nervous system by means of the drug in 1909, Bergmann, Lehmann, Petren u. Thorling and Dresel have carried out researches on this subject. A detailed study of the methods for testing as well as for judging the results of the experiments which they employed has revealed that the conditions in which experiments were conducted varied with each researcher, the results were wilfully distorted and the objective conditions were not in order. Consequently the results of the experiments, which were essentially identical, were interpreted in different ways by each researcher. The theory that various diseases are closely associated with the functioning of the autonomic nervous system primarily or secondarily has been advanced by many researchers and is now taken for granted. To prove this theory entails a fundamental study involving normal persons, which has not been done sufficiently so far, since it merely constituted a part of, and was subordinated to, the study in sick persons. Moreover, the standard for judging the results of the experiments was not always the same. In view of these facts, the author took up. the present investigations for the purpose of contributing to the study of various problems involved in the functioning of the autonomic nervous system in general and to the clarification of the relation between it and the diseases of the skin in particular. Experiments on the pharmacological tests of the functioning of the autonomic nervous system were carried out in 424 normal persons selected from among the inmates of Chiba Prison during the period of one year and eleven months from September, 1950 to July, 1952. The conclusions reached on the basis of the statistical analysis of the results of the present experiments are summarized as follows: (1) Pharmacological tests on the functioning of the autonomic nervous system were performed in 424 inmates of Chiba Prison who were assumed to be normal, using adrenalin, pilocarpine and atropine. (2) Those, whose blood pressures were heightened by more than 31 mmHg. after injections of adrenalin accounted for about 50 % of the total ; those whose blood pressures were heightened by more than 51 mmHg. about 10 %; and those whose blood 'pressures were elevated by more than .61 mmHg. about 5 %. The curve formed on the logarithmic table by 'connecting the points representing the times needed for each case to attain the highest blood pressure was of normal type with the summit at from 20 to 30 minutes. (3) When the elevation of blood pressure (Y) was plotted against the time needed to attain the highest blood pressure (X), the highest blood pressure curve obtained after injections of adrenalin by connecting the points representing the values of the highest blood pressures for each time was expressed by the following formula: Y = 0.04352X^2 - 2.4295X + 185.77 (4) Assuming the average value of the highest blood pressures attained for each time after injections of adrenalin plus, and minus, twice the value of standard deviation to be the upper and lower limits of the normal range for each time, the upper limit curve was diagonal, while the lower limit curve was almost parallel. The time needed to attain the highest blood pressure was between 10 and 35 minutes in 376 cases out of the total of 424 cases under investigations. (5) As standards of sensibility for judging the reactions of the autonomic nervous system, blood pressure was used for adrenalin, slavering for pilocarpine, and pulsation for atropine. Those positive for adrenalin were 48.3 %, for pilocarpine 35.84 % and for atropine 42.68 %. (6) Those who had been moderately and strongly positive were divided according to the time needed to attain the highest blood pressure; thdy were grouped into eight categories according to Ueda's classification; and they were further classified into the following four groups on the basis of the frequency of each case and the degree of elevation of blood pressure: sympatheticotonia, the mixed type, parasympatheticotonia, and non-excessive type. (7) An examination of the relationship between the degree of elevation of blood pressure on the one hand and the increase in the pulse-rate, the increase in the rate of respiration, the degree of elevation of temperature, subjective symptoms and body-weight ratio on the other has revealed that there existed correlation between the degree of elevation of blood pressure and the increase in the pulse-rate, increase in the rate of respiration and subjective symptoms. (8) Until blood pressure has reached 50 mmHg., the elevation of blood pressure. paralleled the increase in the pulse rate. Further elevation of blood pressure brought about a reduction in the increase in the pulse rate. In the ratio of the increase in the pulse rate to the elevation of blood pressure, the cases belonging to 10 minute type showed the smallest value and those belonging to 15 minute and 20 minute types showed the highest ones, with those belonging to 25 minute, 30 minute and 35 minute types showing the intermediate ones. (9) The ratio of the elevation of blood pressure to the subjective symptoms was the largest, and there existed close relation between. them. (10) An examination of the relation between the elevation of blood pressure and the age and temperature by the most strict mathematical computations has disclosed that either the age or temperature should be kept at constant value in evaluating their relationship to the elevation of blood pressure.
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正常人の自律神経機能に就て

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