家兎肺結症核のストレプトマイシンに依る治療実験
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概要
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The author has investigated the effect of streptomycin on the experimentally produced, primary infected and reinfected pulmonary tuberculosis in rabbits. Administration of streptomycin was continued for 35 days tracing its progress by means of chest x-ray examination, and then the animals were killed for the further histological investigation resulting as follows: (1) In the group of primary infection, the treated animals show slightly more improvement than the nontreated control animals do in the following points of view; fading or disappearance of shadows on chest roentgenogram, absence of perifocal inflammation and inhibition against extension or caseation of lesions. In the group of reinfection, on the contrary, the treated animals show more marked improvement on, either roentgenological or histopathological observation than the nontreated control animals do. In other words, the effect of streptomycin on the reinfected animals is more significant than that on the primary infected animals. However, nontreated reinfected animals show some improvement in the above described points of view, although nontreated primary infected animals never show such a improvement in their progress. Therefore, the effect of streptomycin on the reinfected animals appears to be due to the protection by acquired immunity which is also accelerated by the administrated streptomycin. (2) No marked differences were clarified between the primary infected and reinfected groups, if the treatment was started within a short period after inoculation. (3) Occurence of tuberculous allergic inflammation could not be inhibited by administration of streptomycin. (4) In the treated reinfection group animals presented the findings of slaty induration, which often appeared in human pulmonary tuberculosis treated by the chemotherapeutic regimens for long duration. Thus the author suggests the possibility that theslaty induration is affected by streptomycin to some extent.
- 千葉大学の論文