循環器障碍に際しての循環血液量に就て
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概要
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The author carried out investigations on the changes in blood volume in circulation by means of Congo red dye method and hematocrit in 33 cases of valvular disturbances, hypertension and miocarcliac degeneration that caused circulatory disorder. The observations made were compared with various clinical symptoms so that some sort of relationship might be established between the two. The results of the investigations disclosed that higher the degree of circulatory disorder, the larger became the blood volume in circulation in the majority of cases under study, but there were some, though the number was small, that manifested no increase in the blood volume although they were suffering from high degree of circulatory disorder. They might be called " metabolic disturbance of oligemia." A research into the cause of why the blood volume behaved in this manner revealed some interesting. observations. In the metabolic disturbance of high degree, a high degree of dropsy occurred both in the cases in which blood volume was increased and those in which blood volume did not increase, but in the latter serum protein levels, especially the ratio of albumin to globulin, were marked lowered. It will readily be seen that this phenomenon is due to an increase in the consumption of albumin brought about by the multiplication of acid matters in the tissues because of the high degree of disturbance. The resultant difference in the colloidosmotic pressure of the blood would have influenced the transfer of serous fluid between the blood and the tissues. To sum up, there existed close relationship between the behavior of blood volume in circulation and the gegree of metabolic disturbance and dropsy.
- 千葉大学の論文