副腎皮質機能に関する研究 : 副腎皮質機能を中心として観察した発熱の種々相
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概要
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Practising Thorn's adrenocortical reserve function test by ACTH and anterior pituitary adrenocortical integrity test by adrenalin, and also trying basal metabolism and specific dynamic action tests, I have investigated human defence reaction at the time of fever. As a typical infections one, 1 adopted especially the fever caused by T.T.G. (pyrogenbacterial polysaccharides prepared from Gram negative, nonpathogenic Pseudomonas fluorescens) and proved by number of circulating eosinophils in the blood, adrenal ascorbic acid values and histological studies of the adrenal glands that it became Stress by human reaction. It was recognized that this fever worked on nontoxic, on the contrary it stimulate useful defence mechanism and, in consequence, that it can be applied to clinical treatments or diagnosis. From this point of view, the various cases of fever (especially slight fever), were examined. And the results are following. (1). Tuberculosis : Most cases in slight fever do normal eosinopenic response to Thorn's test. (2). Nontuberculous bacterial infectious disease: Many cases do not eosinopenic response to Thorn's test enough. A dosage of T.T.G. makes pituitary adrenocortical function and it is very effective to defence of infection. (3). Premenstrual hyperthermia: This case is thought to be a hyperthermia caused by the disorder of physical heatregulation. In this case, the eosinopenic response to adrenalin is not so enough as others. I think it is due to the secretion of corpus luteum hormone. (4). Hyperthyroidism: The principal factor of slight fever is thought to be caused by surplus heat production. There are two groups; one do eosinopenic response to Thorn's test enough and the other do not. (5). Essential hyperthermia: In this case, through all experiments, the abnormality of adrenocortical function has not been proved. It is, so to speak, not the case that is influence a by Stress of infection, but a hyperthermia on account of decreased heat loss caused by abnormal physical heatregulation. Though it does not respond to any antipyretic agents, it is broken by autonomic blocking agents. (6). The Others: Anemia and malignant tumor patients in slight fever often have weak anterior pituitary adrenocortical. integrity. In the case of central slight fever, many fevers are broken by a administration of ACTH or T.T. G. I would like to insist it is because these medicines alter heatregulating center in the hypothalamus, stimulate the activity of pituitary adrenocortical function, brings "good" clinical responses.
- 千葉大学の論文
- 1955-03-28