頸部淋巴腺結核の化学療法特にTb1について

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概要

• 論文の詳細を見る

• The author examined and confirmed the effects of Tb 1 (Tb 1/698) synthesized in Japan on tuberculosis of the cervical lymphatic nodes by carrying out clinical observations of the lesions as well as general conditions of patients in chronological sequence. Histopathological observations were also carried out in some of the patients examined. In the investigation,different methods in administering the drug were tried, i.e. administration from mouth, injection into the lesion and a combination of administration from mouth with injection into the lesions in order to evaluate the merits of various methods. Patients treated with other antibiotic agents, such as PAS, streptomycin and isoniazid were used as controls. The results have shown that administration of Tb I. from mouth is most efficacious and injection into the lesions is slightly inferior in efficacy requiring caution in the treatment because it causes inflammation at the beginning. A combination method is similar in results to injection into the lesions. It was noticed that there existed close relations between improvements or worsening of chest roentgenographic shadows and the results of treatment. Blood tests revealed that neither reduction of large degree in the amount of leukocytes nor agranulocytosis occurred as the result of administration of Tb 1. Both administration from mouth and injection into the lesions of the drug brought about marked improvements in erythrocyte sedimentation rates. It would be possible to use erythrocyte sedimentation values as an index of the efficacy of treatment. As its side action, administration of Tb 1 caused disturbance of the central nervous system as well as gastroenteric disorder. These complications, however, soon disappeared posing no serious problems. Administration of Tb 1 from mouth contributed . significantly to expediting of natural healing of the lesions from the viewpoint of histology.In about ten weeks demarcation between the lesions and surrounding tissues became clearly distinguishable and eventual encapsulation of the lesions became noticeable. Injection of Tb 1 into the lesions tended to cause non-specific inflammation due to the stimulation given by the drug but it also was responsible for the healing of lesions by formation of connective tissues. A combination method was similar in results to injection into the lesions. Administration of PAS from mouth was similar in results to administration of Tb 1 from mouth. Injection of streptomycin into the lesions was responsible for early recovery, demarcation of caseous lesions becoming distinguishable in about five weeks. Injection of isoniazid into the lesions was similar in results to injection of streptomycin, demarcation of caseous lesions becoming distinguishable in about seven weeks.

• 千葉大学の論文
• 1954-09-28

著者

• 加瀬 孝

  千葉大学医学部

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• 頸部淋巴腺結核の化学療法特にTb1について
• 12. 頸部淋巴腺結核の化学療法を施せる症例の病現像(第315回千葉医学会例会,河合外科学会連合会)

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