栄養失調症骨組織の病理解剖組織学的所見に就て
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概要
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The osseous tissues from 18 autopsy cases of human malnutrition (1945-1946) were histologically examined. These cases include the genuine malnutrition and malnutrition with complication such as pneumonia or enteritis. On the other hand, the osseous tissues of 13 dogs suffering from malnutrition and 6 dogs suffering from starvation were also histologically examined. These experimental cases may be classified into three groups according to the pathological bone changes. By comparatively examining all these materials, following results were obtained: 1) The outstanding changes in the osseous tissues are the remarkably increasing resorption in cases of malnutrition. And resorption is due to the irregular lacunar resorption or due to the penetration of perforating canals, which contain capillaries, through the bone lamelle, or due to the other forms. Based on the pathologic findings on the malnutrition Prof. N. TAKIZAWA expressed his opinion that injured capillary or disturbance of circulation and so-called serous inflammation on the malnutrition resulted from nutritional toxicosis that is due to metabolic disorders following prolonged inharmonious nutrition. (1946). In G. POMMERs and GUNKELs opinions the increasing resorption is in some cases caused by the disturbance of circulation with injured blood vessels or hyperemia and by increasing pressure of blood and tissues in the osseous tissues. In the osseous tissues of the human andexperimental malnutrition the resorption is intimately connected with capillaries and disturbance of circulation or hyperemia. Therefore, the increasing resorption in the osseous tissues seems to have resulted also from nutritional toxicosis, which injured the capillary and caused so-called serous inflammation on the malnutrition. 2) The correlation between the salivary glands and the osseous tissues was observed. In the cases of human malnutrition and experimental malnutrition of slight and moderate degrees, the hypertrophy and multiplication of the striated tubule of the salivary glands and active addition of the bone on the trabeculae in the osseous tissues mostly occured. Normal addition of the bone on the trabeculae was observed in some cases. In the cases of human malnutrition with complication and experimental malnutrition of severe degrees, the degenerative atrophy of salivary glands and the decrease of addition of bone on the trabeculae in the osseous tissues mostly occured. That osteoporosis appears in a slight degree on the genuine malnutrition and experimental malnutrition of slight and moderate degree, and appears in a high degree on the malnutrition with complication and experimental malnutrition of severe degrees. 3) The osseous tissues of the dogs, suffering from experimental starvation, indicated atrophy due to the decrease or ceasing of bone formation without any remarkable resorption. It is evident that the bone changes of the starvation are different from that of the malnutrition. From these observations it is concluded that, firstly, the bone changes of the malnutrition are caused rather by nutritional toxicosis due to metabolic disorders following prolonged inharmonious nutrition than by mere nutritional deficiency and., secondly, the bone changes are closely concerned with internal secretion of salivary glands. Thus the characteristic microscopic features of osteoporosis on the malnutrition were recognized.
- 千葉大学の論文
- 1954-07-28