実験的家兎肺結核症に関する研究 : 第1編無感作感作比較実験

概要

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Two groups of rabbits, sensitized and non-sensitized, were infected intratracheally by human type of tubercle bacilli (Culture of the first generation), followed their progresses by taking chest X-ray, and investigated histologically after their death. The results are as follows: 1) In the sensitized group they develop the paravertebral homogeneous concentrated infiltration on X-ray film due to the sublobar tuberculous pneumonia within 48 hours after the exposure, however, later on these lesions are resorbed and develop the acinous productive type of tuberculosis more than about five weeks later. 2) In the non-sensitized group the pathological changes progress quite sluggish, however, always exacerbated resulting in the condition of lobar caseous pneumonia or cavity formation. But in required about 10 to 14 days to develop the above lesions such as large enough to be revealed on the X-ray film. 3) Thus Koch's phenomenon in the lungs was evidently recognized roentgenologically and histologically by our experiments. 4) The lobar caseous pneumonia, which may suggest allergic nature, is obtained in primary infection of tuberculosis by our experiment. It may be due to the fact that the rabbits were given a large amount of highly virulent bacilli. As to histologic picture there is a considerable difference between human and rabbits.
千葉大学の論文
1953-09-28