肺病巣内結核菌の螢光顕微鏡法による研究
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(1) Materials and Method. Using 79 specimens of the lungs from tuberculous patients treated with resection therapy and 21 specimens of the lungs from the dead bodies of tuberculous patients who had not received chemotherapy, all stained with fluorescent dyes, investigations were carried out on the forms of tubercle bacilli, as well as on the distribution of the bacilli in relation to histologic changes of the lung tissue, with fluorescence microscope. Studies were also made on the effect of chemotherapy on tubercle bacilli in the lesion and the sputum. (2) Results. 1. Fluorescence microscopy is of value in the study of tubercle bacilli in the tissue. 2. Tubercle bacilli in the lesion which multiplied on culture were long, rod-shaped and size, while those which did not multiply on culture were of varying shape and size, small and short, many of them being granule- or mass-shaped. 3. The distribution of tubercle bacilli in encapsulated caseous lesions in resected specimens of the lungs was considerably different from that of tubercle bacilli in tuberculous lesions in specimens of the lungs from the dead bodies. In the former, tubercle bacilli were detected in not only the tissue that had undergone softening but also the tissue that had not yet undergone softening. They were detected in the capsule also. Many bacilli were detected even in the tuberculous lesion with a high degree of fibrotic encapsulation. 4. In the caseous cavity, there were a greater number of bacilli in the top layer of the necrosed portion than in the granulation layer. This was the case with both resected specimens and specimens from the dead bodies. There was almost no bacillus in the granulation layer in the lung specimens from the dead bodies. 5. 24 per cent of encapsulated caseous lesions and 78 per cent of caseous cavities were positive for tubercle bacilli on culture.Many encapsulated caseous lesions became negative for tubercle bacilli after an initial course of chemotherapy, while many caseous cavities remained positive for tubercle bacilli after a course of chemotherapy, whether it be an initial or a repeat one. 6. The tuberculous lesion had a higher rate of positivity for tubercle bacilli on culture than the sputum. Tubercle bacilli in the former were more resistant to antibiotics than the latter.
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- 肺病巣内結核菌の螢光顕微鏡法による研究