胎児性軟骨異栄養症の病理解剖学的研究
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概要
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Besides the constitutional and mechanic theories, till today, various hormonal theories have been known about this disease, such as hypophyseogen, thyreogen, parathyreogen, thymogen and genital theories etc. The author summarised 11 autopsy cases ( fetal 8 cases, postnatal 3 cases) of typical fetal chondrodystrophia by courtesy of 6 Universities, and investigated them pathomorphologically with the following results. 1. Chondrodystrophia fetalis is the systematic disease not only of the cartilage and bone tissue, but also of another mesenchymal tissue etc., such as connective tissue, elastic fiber, fat tissue and cutis etc. For the above reason, "Mesenchymodystrophia (OGATA)" is most adequate to summarize these pathologic changes. 2. Microscopically, the salivary glands (parotid and submaxillary glands) of all above cases are apparently hypoplastic, compared with those of normal development. Further, the other insecretory organs indicate certain secondary pathologic changes, which were observed in the experimental "Asialadenism (OGATA)". Since the author regards the cause of this disease as the hypofunction of internal secretion of the salivary glands, especially of parotid glands, this disease should be classified in the "Osteoarthrosis chondromalacica (OGATA)" in connection with Kaschin-Beck's disease and arthropathia deformance senilis. 3. In cases of malacic form, in the epiphyseal cartilage surrounding the chondromalacic foci, the author described two types of unmasking of intercellular fibrillar structure; i.e. unmasking of so-called asbest-fiber and of something like elastic-fiber. 4. In the postnatal case treated with "Parotin" (hormone of salivary glands), the growth of epiphyseal cartilage is apparently accelerated, simultaneously with the clinical course.
- 千葉大学の論文