Characterization of a novel rat gene RTAP2a, screened by cross-reactive SEREX, restrictedly expressed in testis(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
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概要
- 論文の詳細を見る
Genes involved in tumorigenesis may be targets for cancer immunotherapy. For many tumor types, molecular signatures do not yet exist. Methods that identify novel, tissue-specific tumor-related genes therefore have potentially important implications for developing cancer immunotherapy. Here, we used cross-reactive serological analysis of recombinant cDNA expression (CR-SEREX) to identify the novel testicular cancer-related gene, rat testicular antigenic protein 2 (RTAP2). We identified two RTAP2 splice variants (RTAP2a and RTAP2b) encoding 191 and 358 amino acid proteins, respectively. RTAP2a and RTAP2b proteins have identical N-termini but different C-terminal regions arising from alternative splicing of exon 4. Bioinformatics and reverse transcription-polymerase chain reaction (RT-PCR) revealed that the RTAP2a transcript was expressed selectively in adult testis and several tumor cell lines, while RTAP2b was ubiquitous. Our results suggest that RTAP2a may contribute to testicular development and tumorigenesis, and may be a candidate gene for cancer immunotherapy.
- 社団法人日本生物工学会の論文
著者
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Peng Feng
Department Of Thoracic Oncology Of Cancer Center And State Key Laboratory Of Biotherapy West China H
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Wang Rui
State Key Laboratory Of Biotherapy West China Hospital West China Medical School Sichuan University
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Wei Yuquan
Department Of Thoracic Oncology Of Cancer Center And State Key Laboratory Of Biotherapy West China H
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Zhang Peng
Department Of Urology West China Hospital Sichuan University
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Zhang Peng
Department Of Radiation Oncology Sichuan Cancer Hospital
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Yang Hanshuo
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan Universi
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Wang Chunting
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan Universi
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Deng Hongxin
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan Universi
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Ding Zhenyu
Department of Thoracic Oncology of Cancer Center and State Key Laboratory of Biotherapy, West China
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Yang Jinliang
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan Universi
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Lu You
Department of Thoracic Oncology of Cancer Center and State Key Laboratory of Biotherapy, West China
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Li Jiong
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan Universi
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Mao Yongqiu
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan Universi
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Kan Bing
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan Universi
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Wei Lin
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan Universi
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Lu You
Department Of Thoracic Oncology Of Cancer Center And State Key Laboratory Of Biotherapy West China H
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Kan Bing
State Key Laboratory Of Biotherapy West China Hospital West China Medical School Sichuan University
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Li Jiong
State Key Laboratory Of Biotherapy West China Hospital West China Medical School Sichuan University
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Ding Zhenyu
Department Of Thoracic Oncology Of Cancer Center And State Key Laboratory Of Biotherapy West China H
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Mao Yongqiu
State Key Laboratory Of Biotherapy West China Hospital West China Medical School Sichuan University
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Yang Hanshuo
State Key Laboratory Of Biotherapy West China Hospital West China Medical School Sichuan University
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Wang Chunting
State Key Laboratory Of Biotherapy West China Hospital West China Medical School Sichuan University
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Yang Jinliang
State Key Laboratory Of Biotherapy West China Hospital West China Medical School Sichuan University
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Deng Hongxin
State Key Laboratory Of Biotherapy West China Hospital West China Medical School Sichuan University
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Li Jiong
State Key Laboratory Of Biotherapy And Cancer Center West China Hospital West China Medical School S
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Mao Yongqiu
State Key Laboratory Of Biotherapy And Cancer Center West China Hospital West China Medical School S
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Deng Hongxin
State Key Laboratory Of Biotherapy And Cancer Center West China Hospital West China Medical School S
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Zhang Peng
Department Of Dermatology Epigenetic Research Center Second Xiangya Hospital Central South Universit
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Zhang Peng
Department Of Anesthesiology Qilu Hospital Affiliated With Shandong University
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Wei Lin
State Key Laboratory Of Biotherapy West China Hospital West China Medical School Sichuan University
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