Evaluation of genotoxicity of amine-terminated water-dispersible FePt nanoparticles in the Ames test and in vitro chromosomal aberration test
スポンサーリンク
概要
- 論文の詳細を見る
Genotoxicity of superparamagnetic iron-platinum (FePt) nanoparticles (NPs) capped with 2-aminoethanethiol (AET) was evaluated using the bacterial reverse mutation assay (Ames test) and in vitro chromosomal aberration test. Mutagenicity of AET-capped FePt NPs was found to be negative in the Ames test, while clastogenicity of FePt NPs seemed to be false-positive in the in vitro chromosomal aberration test using Chinese hamster lung fibroblast cells. However, further detailed in vitro genotoxicity tests, such as DNA adduct studies, are necessary to conclude that a positive aberration result is irrelevant.
- 2009-06-01
著者
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Yoshida Rie
School Of Materials Science Japan Advanced Institute Of Science And Technology
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Maenosono Shinya
School Of Materials Sci. Japan Advanced Inst. Of Sci. And Technol.
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SAITA Soichiro
Mitsubishi Chemical Group Science and Technology Research Center, Inc.
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Saita Soichiro
Mitsubishi Chemical Group Science And Technology Research Center Inc.
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Saita Soichiro
Mitsubishi Chemical Corporation Yokohama Research Center
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