Analysis of phthalate derivatives in Kampo medicinal products

概要

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Recently, food safety has become an increasingly important issue in Japan. Currently, most natural medicines used in Japan are dependent on imports from China. In the future, further economic development of China is expected, and various materials are produced will be released throughout the environment. In this study, we paid increased attention to the phthalate derivatives, and performed quantitative analysis by HPLC of extractions through boiling of five kinds of natural medicines and the extraction of 18 kinds of Kampo medicinal products. As a result, 7 kinds of phthalate derivatives except bis-2-ethylhexyl phthalate (DEHP) were detected in natural medicines. Among Kampo medicinal products, di-n-butyl phthalate (DBP) was detected in all products tested except daikenchuto and keigairengyoto, high levels of diethyl phthalate (DEP) was detected in shoseiryuto and di-n-pentyl phthalate (DPP) and DEHP were detected only in tokishakuyakusan. di-n-hexyl phthalate (DnHP) was not detected in any of the Kampo medicinal products tested.