The Effect of Generation 2 and 3 Poly (amidoamine) Dendrimers on Viability of Human Breast Cancer Cells
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概要
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In this study, we investigated the effect of amine- and hydroxyl-terminated Generation 2 and 3 (G2 and G3) poly (amidoamine) (PAMAM) dendrimers on the viability and induction of apoptosis in human MCF-7 and MDA-MB-231 breast cancer cells. It was shown that amino-terminated PAMAM dendrimers were cytotoxic, with IC_<50> value after 24hr of incubation in MCF-7 and MDA-MB-231 breast cancer cells 153±3μM and 140±2μM for G2 PAMAM and 120±3μM and 99±2μM for G3 PAMAM, respectively. Experiments made with annexin V-fluorescein isothiocyanate (V-FITC) and detection of apoptosis by a fluorescent microscopy assay revealed that G2 and G3 PAMAM-NH_2 dendrimers inhibited the proliferation of MCF-7 and MDA-MB-231 malignant cells by increasing the number of apoptotic and necrotic cells. The cytotoxic and apoptotic effect of G2 and G3 PAMAM-OH dendrimers was significantly weaker.
- 2009-04-01
著者
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Winnicka Katarzyna
Department Of Pharmaceutical Technology Faculty Of Pharmacy Medical University Of Bialystok
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Bielawski Krzysztof
Department Of Medicinal Chemistry And Drug Technology Faculty Of Pharmacy Medical University Of Bial
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Rusak Magorzata
Department of Hematological Diagnostics, Faculty of Pharmacy, Medical University of Bialystok
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Bielawska Anna
Department of Medicinal Chemistry and Drug Technology, Faculty of Pharmacy Medical University of Bia
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Bielawska Anna
Department Of Medicinal Chemistry And Drug Technology Faculty Of Pharmacy Medical University Of Bial
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Rusak Magorzata
Department Of Hematological Diagnostics Faculty Of Pharmacy Medical University Of Bialystok
関連論文
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