Synthesis, Characterization and Cytotoxicity of Dihalogeno-platinum(II) Complexes with L-Histidine Ligand

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概要

• 論文の詳細を見る

• Diiodo-, dibromo- and dichloro-platinum(II) complexes containing L-histidine ligand were prepared. Their spectra and X-ray crystal structure of the dibromo-platinum(II) complex were described. Only the dichloro-platinum(II) complex showed comparable cytotoxic activity with carboplatin against A549/ATCC, HT 29, and LNcap cell lines. Nevertheless the complexes with COOH-substituted ligands histidine may be good starting materials to synthesize targeting platinum complexes since they could be easily linked to suitable carrier molecules via esterification.

• 公益社団法人日本薬学会の論文
• 2009-04-01

著者

• Chen Xi-zhu

  Platinum-based Drug Lab Kunming Institute Of Precious Metals

• Xie Ming-jin

  School Of Chemistry Yunnan University

• YE Qing-Song

  Platinum-Based Drug Lab, Kunming Institute of Precious Metals

• LIU Wei-Ping

  Platinum-Based Drug Lab, Kunming Institute of Precious Metals

• YU Yao

  Platinum-Based Drug Lab, Kunming Institute of Precious Metals

• CHANG Qiao-Wen

  Platinum-Based Drug Lab, Kunming Institute of Precious Metals

• HOU Shu-Qian

  Platinum-Based Drug Lab, Kunming Institute of Precious Metals

• Yu Yao

  Platinum-based Drug Lab Kunming Institute Of Precious Metals

• Ye Qing-song

  Platinum-based Drug Lab Kunming Institute Of Precious Metals

• Hou Shu-qian

  Platinum-based Drug Lab Kunming Institute Of Precious Metals

• Liu Wei-ping

  Platinum-based Drug Lab Kunming Institute Of Precious Metals

• Chang Qiao-wen

  Platinum-based Drug Lab Kunming Institute Of Precious Metals

関連論文

• Synthesis, Characterization and Cytotoxicity of Dihalogeno-platinum(II) Complexes with L-Histidine Ligand
• Preparation, Characterization and in Vitro Anticancer Activity of Platinum(II) Complexes with N-Cyclohexyl-1,3-propanediamine as the Carrier

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