First Total Syntheses of (±)-Isopiline, (±)-Preocoteine, (±)-Oureguattidine and (±)-3-Methoxynordomesticine and the Biological Activities of (±)-3-Methoxynordomesticine

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概要

• 論文の詳細を見る

• A convenient and economical synthesis of 4-hydroxy-2,3-dimethoxybenzaldehyde has been developed. This was used as the starting material for the first total syntheses of (±)-isopiline, (±)-preocoteine, (±)-oureguattidine and (±)-3-methoxynordomesticine in which the key step involved formation of ring C of the aporphines by a radical-initiated cyclisation. Although (±)-3-methoxynordomesticine possesses weak antimicrobial activity, it inhibits the production of nitric oxide (NO), prostaglandin (PG)E_2, tumor necrosis factor (TNF)-α, interleukin (IL)-1 β and IL-6 and the expression of inducible nitric oxide synthase (iNOS) and cycloxygenase (COX)-2 in macrophages stimulated with LPS in vitro.

• 公益社団法人日本薬学会の論文
• 2009-04-01

著者

• Shen Yuemao

  Kunming Institute Of Botany Chinese Academy Of Science

• Shen Yuemao

  Kunming Institute Of Botany The Chinese Academy Of Sciences

• NIMGIRAWATH Surachai

  Department of Chemistry, Faculty of Science, Silpakorn University

• UDOMPUTTIMEKAKUL Phansuang

  Department of Chemistry, Faculty of Science, Silpakorn University

• TAECHOWISAN Thongchai

  Department of Microbiology, Faculty of Science, Silpakorn University

• WANBANJOB Asawin

  Department of Chemistry, Faculty of Science, Silpakorn University

• Wanbanjob Asawin

  Department Of Chemistry Faculty Of Science Silpakorn University

• Nimgirawath Surachai

  Department Of Chemistry Faculty Of Science Silpakorn University

• Taechowisan Thongchai

  Department Of Microbiology Faculty Of Science Silpakorn University

• Udomputtimekakul Phansuang

  Department Of Chemistry Faculty Of Science Silpakorn University

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• P-59 CHEMICAL CONSTITUENTS OF LIGULARIA VIRGAUREA AND ITS DIVERSITY IN SOUTHWESTERN SICHUAN OF CHINA
• Chemical and Genetic Differentiation of Ligularia pleurocaulis in Northwestern Yunnan and Southwestern Sichuan Provinces of China
• First Total Syntheses of (±)-Isopiline, (±)-Preocoteine, (±)-Oureguattidine and (±)-3-Methoxynordomesticine and the Biological Activities of (±)-3-Methoxynordomesticine

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