Fabrication and Evaluation of Taste Masked Resinate of Risperidone and Its Orally Disintegrating Tablets
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概要
- 論文の詳細を見る
The present investigation was undertaken to design a simple, rapid, cost effective and highly efficient process to fabricate a tasteless complex of risperidone using ion exchange resin (IER), evaluate the molecular properties of the resinate and finally incorporate it into orally disintegrating tablets (ODT). The resinate formation using Amberlite IRP64, was confirmed using the characterization methods: Fourier transform-infrared (FT-IR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The maximum loading efficiency achieved was 99.72±0.16% in 1:4 (drug:resin weight) ratio at pH 6.0, temperature at 22℃ in a period of 1.5h using ethanol:water (1:1, v/v) as the complexation medium. The complex was compressed into orally disintegrating tablet. The drug release from the complex was about 2.5% in 120s in 5ml of pH 6.8 phosphate buffer which has been used to mimic the salivary fluid volume and pH. Dissolution studies using 500ml of 0.1N HCl at 50rpm in USP Apparatus II released 92% in 5min, indicating complete drug release from the complex in the stomach. Resinate was tasteless while the fabricated ODTs were pleasantly tasting without any bitterness of drug as confirmed by the taste panel.
- 公益社団法人日本薬学会の論文
- 2009-04-01
著者
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Singh Sanjay
Department Of Pharmaceutics Institute Of Technology Banaras Hindu University
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Shukla Dali
Department Of Pharmaceutics Institute Of Technology Banaras Hindu University
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MISHRA Brahmeshwar
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University
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Chakraborty Subhashis
Dep. Of Pharmaceutics Inst. Of Technol. Banaras Hindu Univ.
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CHAKRABORTY Subhashis
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University
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Mishra Brahmeshwar
Department Of Pharmaceutics I. T. Banaras Hindu University
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