培養歯髄細胞でのFGF8によるMSX-1誘導に関する細胞内情報伝達機構に関する研究

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MSX-1 is a member of the homeobox family, which plays important roles in industive tissue interactions during vertebrate organogenesis. As mice deficient in MSX-1 demonstrated tooth morphogenesis failure, MSX-1 could be a key factor controlling inductive signaling molecules between the dental epithelium and mesenchyme during tooth formation. Furthermore, it has been found that FGF8 expressed in dental mesenchyme induced MSX-1 in dental mesenchyme in early tooth development. These results indicated that the relationship between FGF8 and MSX-1 could be an important clue to elucidate dentinogenesis; however, few papers have studied the signaling pathways of MSX-1 expression induced by FGF8 in dental mesenchyme. In this study, we found that MSW-1 was induced by FGF8 throughout mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) in cultured dental pulp cells isolated from rat lower incisors. When MAPK/ERK activation was inhibited with a specific inhibitor (PD98059), MSX-1 expression was remarkably reduced. The specific inhibitor also significantly reduced MSX-1 expression induced by FGF8. Interestingly, the inhibitor had no effect on alkaline phosphatase, but blocked the cell proliferation stimulated by FGF8. These results suggest that MAPK/ERK is necessary for MSX-1 expression induced by FGF8, and plays important roles in dentinogenesis in rat dental mesenchymal cells.
特定非営利活動法人日本歯科保存学会の論文
2006-08-31

培養歯髄細胞でのFGF8によるMSX-1誘導に関する細胞内情報伝達機構に関する研究

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