Both Type-I and Type-II Responses Contribute to Murine Trypanotolerance(Immunology)

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概要

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• The host immune system has been documented to influence the course and outcome of infection with the phospholipase-C-deficient (PLC^<-/->) Trypanosoma brucei brucei. We addressed the resistant mechanisms during trypanosomosis by comparing the immune response to variant-specific surface glycoprotein (VSG) in relatively susceptible C3H mice and trypanotolerant (C57BL/6×BALB/c)-F1 (B6B-F1) mice infected with PLC^<-/-> parasites. During the early stage of infection, lymphoid cells from both PLC^<-/->-susceptible C3H and -tolerant B6B-F1 mice mainly secreted VSG-specific IFN-γ. Although C3H mice remained locked in a type-I cytokine environment (IFN-γ, TNF-α) during late stage of infection, B6B-F1 mice switched to production of type-II cytokines (IL-4, IL-10) from late stage of infection onwards. It seems that VSG-specific cytokine responses associated with resistance to murine African trypanosomosis are infec-tion-stage dependent, with type-I cytokine responses being critical during the early stage of infection while type-II cytokine responses appear to be more important during the late and chronic phases of the disease. Because of the striking similarities in the course of the PLC^<-/-> infection in B6B-F1 mice with that of the trypanotolerant N'dama cattle naturally-infected with T. congolense, the PLC^<-/->-infected B6B-F1 mice represents a suitable model to study the course of infection and immune responses during bovine trypanosomosis.

• 社団法人日本獣医学会の論文
• 2009-03-25

著者

• Namangala Boniface

  The University Of Zambia Faculty Of Veterinary Medicine Department Of Paraclinical Studies:departmen

• BAETSELIER Patrick

  Department of Cellular and Molecular Interactions, Flanders Interuniversity Institute for Biotechnol

• BESCHIN Alain

  Department of Cellular and Molecular Interactions, Flanders Interuniversity Institute for Biotechnol

• Beschin Alain

  Department Of Cellular And Molecular Interactions Flanders Interuniversity Institute For Biotechnolo

• De Baetselier

  Department Of Cellular And Molecular Interactions Flanders Interuniversity Institute For Biotechnolo

• Baetselier Patrick

  Department Of Cellular And Molecular Interactions Flanders Interuniversity Institute For Biotechnolo

関連論文

• Quantitative Differences in Immune Responses in Mouse Strains that Differ in their Susceptibility to Trypanosoma brucei brucei Infection
• Both Type-I and Type-II Responses Contribute to Murine Trypanotolerance(Immunology)

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