Acute and Subacute Toxicity of Copper Sulfate Pentahydrate (CuSO_45・H_2O) in the Guppy (Poecilia reticulata)(Toxicology)

概要

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Chemicals are used for treatment of aquatic diseases, but there is little data available about copper sulfate in small ornamental fish. The aim of the present study was to determine the TLm_<24h> and evaluate the toxicity of copper sulfate in the guppy (Poecilia reticulata). The fish were subjected to an acute toxicity test for 24hr, and the results showed a TLm_<24h> value of 1.17ppm. Severe hyperplasia and exfoliation of the epithelial cells of gill lamellae and obstruction of the internal cavities of renal tubules with necrotized renal epithelial cells sloughed from the basement membrane were observed. However, no significant changes, except for mild curling of gill lamellae, were found in a subacute toxicity test in which fish were exposed to 1/10 of the TLm_<24h> value for 1 week. Therefore, use of less than 0.12ppm of copper sulfate may be recommended as a therapeutic level.
社団法人日本獣医学会の論文
2009-03-25