Collaborative work on evaluation of ovarian toxicity : 4) Effects of fertility study of 4-vinylcyclohexene diepoxide in female rats
スポンサーリンク
概要
- 論文の詳細を見る
As part of a collaborative project, 4-vinylcyclohexene diepoxide (VCD), an ovarian toxicant, was intraperitoneally administered to female Sprague-Dawley rats at 0, 5, 20 or 80mg/kg from 2 weeks prior to mating to Day 7 of gestation. At necropsy, the number of implanted embryos, rate of implantation decreased and the rate of preimplantation loss showed an increasing tendency in the 80mg/kg group. As for organ weight, decreases in absolute and relative ovary weight were observed in the 80mg/kg group. Histopathologically, the ovaries showed a decrease in number of small follicles at 80mg/kg.
- 日本トキシコロジー学会の論文
著者
-
Miwa Tadashi
Toxicology And Pathology Nonclinical Developmental Research Department Pharmaceutical Research Labor
-
Kodama Terutaka
Toxicology And Pathology Nonclinical Developmental Research Department Pharmaceutical Research Labor
-
Masuyama Takeshi
Toxicology And Pathology Nonclinical Developmental Research Department Pharmaceutical Research Labor
-
Yoshida Junichi
Toxicology and Pathology, Nonclinical Developmental Research Department, Pharmaceutical Research Lab
-
Hasegawa Daiki
Toxicology and Pathology, Nonclinical Developmental Research Department, Pharmaceutical Research Lab
-
Yoshida Junichi
Toxicology And Pathology Nonclinical Developmental Research Department Pharmaceutical Research Labor
-
Hasegawa Daiki
Toxicology And Pathology Nonclinical Developmental Research Department Pharmaceutical Research Laboratories Pharmaceutical Company Ajinomoto Co. Inc.
関連論文
- Collaborative work on evaluation of ovarian toxicity : 4) Effects of fertility study of 4-vinylcyclohexene diepoxide in female rats
- A 4-week Repeated Dose Toxicity Study of Glycine in Rats by Gavage Administration