<Reviews>Molecular Mechanism of Glucose Transport in Skeletal Muscle
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概要
- 論文の詳細を見る
The AMP-activated protein kinase (AMPK) is an energy-sensing enzyme that is activated by decrease in intracellular energy level that is accompanied with an acute increases in the cellular [AMP]/[ATP] ratio (1). In skeletal muscle, AMPK activity is increased by stimuli such as exercise, hypoxia, ischemia, and osmotic stress. There are many lines of evidence that increasing AMPK activity in skeletal muscle results in increased rates of glucose transport. LKB1 is a Ser/Thr kinase that is thought to be a master regulator for a diverse array of cellular processes. It has been well documented that LKB1 regulates skeletal muscle metabolic processes. Our group (Dr Goodyear's group, Boston) and others have generated mice lacking AMPK activity in skeletal muscle (2) as well as muscle-specific LKB1 knockout mice (3). Using these animal models, the potential roles of the LKB1-AMPK signaling axis in regulating skeletal muscle glucose transport have been studied for a couple of years.
- 日本運動生理学会の論文
著者
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FUJII Nobuharu
Department of Internal Medicine II, Okayama University Medical School
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Fujii Nobuharu
Department Of Health Promotion Sciences Graduate School Of Human Health Sciences Tokyo Metropolitan
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