Effect of N-acetylcysteine on Radiation-induced Genotoxicity and Cytotoxicity in Rat Bone Marrow
スポンサーリンク
概要
- 論文の詳細を見る
The aim of this study is to evaluate the potential radioprotective effects of N-acetylcysteine (NAC) against genotoxicity and cytotoxicity. The effect of WR-2721, as a representative of clinically used radio-protector, was compared with that of NAC, using the chromosomal aberration (CA) and micronucleus (MN) test systems in the irradiated rat's femoral bone marrow cells. We also investigated the mitotic index (MI), and the ratio of polychromatic erythrocytes (PCEs) to normochromatic erythrocytes (NCEs). The rats (n=16) were divided randomly and equally into four groups: Control (C), Radiation (R), R+NAC (received irradiation and 1000mg/kg NAC) and R+WR-2721 (received irradiation and 200mg/kg WR-2721) rats. All the irradiated groups received whole-body gamma irradiation as a single dose of 6 Gy. Group R showed higher CA and MN formation when compared to C. Group R showed higher frequency of MN formation when compared to both R+NAC and R+WR-2721. The mean MI and PCE/NCE ratios were lower in Group R when compared to those of Group C. The mean MI and PCE/NCE ratios of both R+NAC and R+WR-2721 groups were lower when compared to those of Group C. The MI in Group R was lower when compared to that of both R+NAC and R+WR-2721 groups. In this study, the results give clues about the beneficial effects of NAC against radiation-induced genotoxicity and cytotoxicity in rat bone marrow and its effect may be comparable to that observed for WR-2721.
- 日本放射線影響学会の論文
- 2009-01-16
著者
-
Demirel Can
Department Of Biophysics Faculty Of Medicine Gaziantep University
-
KILCIKSIZ Sevil
Department of Radiation Oncology, Faculty of Medicine, Gaziantep University
-
AY Ozlem
Department of Medical Biology, Faculty of Medicine, Mersin University
-
GURGUL Serkan
Department of Biophysics, Faculty of Medicine, Mersin University
-
AY M.
Department of Medical Biology, Faculty of Medicine, Mersin University
-
ERDAL Nurten
Department of Medical Biology, Faculty of Medicine, Mersin University
-
Ay M.
Department Of Medical Biology Faculty Of Medicine Mersin University
-
Ay Ozlem
Department Of Medical Biology Faculty Of Medicine Mersin University
-
Erdal Nurten
Department Of Medical Biology Faculty Of Medicine Mersin University
-
Gurgul Serkan
Department Of Biophysics Faculty Of Medicine Mersin University
-
Kilciksiz Sevil
Department Of Radiation Oncology Faculty Of Medicine Gaziantep University
-
Erdal Nurten
Department of Biophysics, Faculty of Medicine, Mersin University
関連論文
- Effects of Long-term Exposure of Extremely Low Frequency Magnetic Field on Oxidative/Nitrosative Stress in Rat Liver
- Effect of N-acetylcysteine on Radiation-induced Genotoxicity and Cytotoxicity in Rat Bone Marrow
- MRI-guided attenuation correction in whole-body PET/MR : assessment of the effect of bone attenuation