Inhibition of hypertonic saline induced cough by Loratadine in nonasthmatic patients with chronic cough

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We examined the effect of loratadine（ 10mg） on the number of coughs induced by ultrasonically nebulizedhypertonic saline in nine patients with chronic cough and in ten normal volunteers using a randomized， double-blind cross-over method. Each subject inhaled hypertonic saline for one minute， and the numbers ofcoughs during the one-minute 4.5% NaCl inhalation and the 30-second period following 4.5% NaCl inhalationwere counted. There was no difference in forced expiratory volume in one second （ FEV1） or maximumexpiratory flow at 25% vital capacity （ V25） before to after one-minute hypertonic saline inhalation for eitherpatients or normal subjects. There was also no significant difference in FEV1 or V25 before to one hour afteroral administration of loratadine. Placebo did not reduce the number of induced coughs for either patientsor normal subjects， but loratadine significantly reduced the number of coughs for patients with chronic cough（P＝0.012）. On the other hand， loratadine did not reduce the number of coughs by normal subjects. Weconclude that in patients with chronic cough， the release of histamine or other chemical mediators or highsensitivity of cough receptors to histamine may be one of the reasons for persistence of chronic cough.
武庫川女子大学の論文