Validation of HPLC-UV Methods for Quantitatively Determining Landiolol and Its Major Metabolite in Human Blood(Analytical Biochemistry)
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概要
- 論文の詳細を見る
Landiolol is an ultra-short-acting β_1-adrenergic receptor blocking agent that is used for both perioperative and postoperative patients with tachycardia during general anesthesia. Validated HPLC-UV methods that quantitatively determine landiolol and its major metabolite (M-1) in human blood were reported for clinical research of landiolol. These analytes were recovered from the same blood sample using a multi-step extraction process and determined with two different HPLC conditions. These methods were validated over concentration ranges of 0.05 to 10μg/ml for landiolol and 0.1 to 20μg/ml for M-1 and were found to have acceptable accuracy, precision, linearity, and selectivity. These methods are useful to the characterize of blood pharmacokinetics of landiolol and M-1 for clinical research.
- 社団法人日本薬学会の論文
- 2009-01-01
著者
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MIYATA Yasuyuki
Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd.
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Hashimoto Yoshitaka
Pharmacokinetic Research Laboratories Research Headquarters Ono Pharmaceutical Co. Ltd.
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Miyata Yasuyuki
Pharmacokinetic Research Laboratories Research Headquarters Ono Pharmaceutical Co. Ltd.
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NAGO Sachiko
Pharmacokinetic Research Laboratories, Research Headquarters, Ono Pharmaceutical Co. LTD.
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SHIBAKAWA Kimio
Pharmacokinetic Research Laboratories, Research Headquarters, Ono Pharmaceutical Co. LTD.
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TSUNEKAWA Masako
Pharmacokinetic Research Laboratories, Research Headquarters, Ono Pharmaceutical Co., Ltd.
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Hashimoto Yoshitaka
Pharmacokinetic Research Laboratories Ono Pharmaceutical Co. Ltd.
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Nago Sachiko
Pharmacokinetic Research Laboratories Research Headquarters Ono Pharmaceutical Co. Ltd.
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Miyata Yasuyuki
Pharmacokinetic Research Laboratories Ono Pharmaceutical Co. Ltd.
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Shibakawa Kimio
Pharmacokinetic Research Laboratories Research Headquarters Ono Pharmaceutical Co. Ltd.
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Tsunekawa Masako
Pharmacokinetic Research Laboratories Research Headquarters Ono Pharmaceutical Co. Ltd.
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MIYATA Yasuyuki
Pharmacokinetic Research Institute, Ono Pharmaceutical Co., Ltd.
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