Acetylation of the Amino Group on Guanosine Induced by Nitric Oxide in Acetonitrile under Aerobic Conditions

概要

論文の詳細を見る
When nitric oxide was bubbled into acetonitrile under aerobic conditions, the solution showed a cobalt-blue color. Addition of guanosine into the solution generated N^2-acetylguanosine as a major product. The result of the reaction using ^<15>N labeled acetonitrile indicated that the nitrogen atom of the acetylated exocyclic amino group on N^2-acetylguanosine originated from acetonitrile. We discuss the reaction mechanism for the acylation.
公益社団法人日本薬学会の論文
2009-01-01