β-Ecdysterone Induces Osteogenic Differentiation in Mouse Mesenchymal Stem Cells and Relieves Osteoporosis(Pharmacology)
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概要
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The effect on bone tissue of β-ecdysterone, a type of ecdysteroid found in many plants, has not been previously investigated. In this study, we found that β-ecdysterone treatment significantly induced alkaline phosphatase (ALP) activity in mesenchymal stem cells in a dose-dependent manner. Real-time polymerase chain reaction (PCR) showed that Runx2, osteocalcin, and type I collagen expression also increased. ICI182780, a specific estrogen receptor antagonist, inhibited the upregulation of ALP activity. Moreover, β-ecdysterone promoted estrogen receptor (ER) reporter gene activity; however, ICI182780 reversed its effect, suggesting that β-ecdysterone has stimulatory effects on osteogenic differentiation via the ER. Furthermore, β-ecdysterone alleviated osteoporosis symptoms in a mouse model without obvious side effects. Therefore β-ecdysterone may be a promising candidate drug for the treatment of osteoporosis.
- 公益社団法人日本薬学会の論文
- 2008-12-01
著者
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GAO Lei
Department of Ophthalmology, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College, Qi
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Gao Lei
Department Of Biological Sciences And Biotechnology Tsinghua University:life Science Division Tsingh
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Cai Guoping
Department Of Biological Sciences And Biotechnology Tsinghua University And State Key Laboratory Of
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Cai Guoping
Department Of Biological Sciences And Biotechnology Tsinghua University:life Science Division Tsingh
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SHI Xiaojun
Life Science Division, Tsinghua University Graduate School at Shenzhen
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Shi Xiaojun
Life Science Division Tsinghua University Graduate School At Shenzhen
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