Histamine H_3 Receptor Antagonists Go to Clinics

概要

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Within the recent years novel lead optimisations for histamine H_3 receptor antagonists made their way from bench to bedside. Structure-activity relationships, cross-affinities and side effects as well as pharmacokinetic profiling will be discussed on selected promising compound series. Due to diversity in potential therapeutic applications and in some cases a controversial debate, different indications will be highlighted with the potential and the problems of the test compounds, e.g. sleep-wake disorders, attention-deficient hyperactivity disorder, epilepsy, cognitive impairment, schizophrenia, obesity and neuropathic pain. First data published on clinical trials phase II (IIb) are presented showing proof of concept of H_3 receptor antagonists in narcolepsy and photoinduced epilepsy.
公益社団法人日本薬学会の論文
2008-12-01