Synthesis of Some Pyridazinylacetic Acid Derivatives as a Novel Class of Monoamine Oxidase-A Inhibitors
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概要
- 論文の詳細を見る
A series of new pyridazinylacetic acid derivatives were synthesized and have been investigated for their ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO). All compounds were found to be more selective to the MAO-A isoform with compound 5d having the highest SI values. Computational study performed with a docking technique indicated the potential of these compounds in pyridazine-based MAO-A inhibitor drug development.
- 公益社団法人日本薬学会の論文
- 2008-12-01
著者
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Khattab Sherine
Dep. Of Chemistry Fac. Of Sci. Univ. Of Alexandria
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Khattab Sherine
Department Of Chemistry Faculty Of Science Alexandria University
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El-faham Ayman
Department Of Chemistry Faculty Of Science Alexandria University
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El-faham Ayman
Department Of Chemistry Faculty Of Science University Of Alexandria
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BEKHIT Adnan
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria
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EL MASSRY
Department of Chemistry, Faculty of Science, University of Alexandria
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AMER Adel
Department of Chemistry, Faculty of Science, University of Alexandria
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Bekhit Adnan
Department Of Pharmaceutical Chemistry Faculty Of Pharmacy University Of Alexandria
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Amer Adel
Department Of Chemistry Faculty Of Science University Of Alexandria
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El Massry
Department Of Chemistry Faculty Of Science University Of Alexandria
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- Synthesis of Some Pyridazinylacetic Acid Derivatives as a Novel Class of Monoamine Oxidase-A Inhibitors
- Synthesis and Biological Evaluation of Some Amino-Acid Derivatives as a Novel Class of Monoamine Oxidase-A Inhibitors