Vitamin D receptor gene and exercise : influence on bone mineral density

概要

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The population with osteoporosis is estimated at over ten million people in Japan. The consecutive increase of the case is therefore a serious problem in our aging society. Reducing the risk of bone fractures from osteoporosis involves preventing or delaying the loss of bone mineral density (BMD). BMD has been reported to be strongly determined genetically. The vitamin D receptor (VDR) is a good candidate gene for a prime regulator of BMD and bone metabolism. Many allelic variants in the VDR gene have been associated with BMD. In addition to the genetic background, exercise is also related to BMD. Recently, there is a growing realization that the physical response to a particular exercise stimulus may be mediated by individual genetic variability. This review briefly summarizes the influence of VDR polymorphism and exercise on BMD.
大阪河崎リハビリテーション大学の論文