タイプ2イソペンテニル二リン酸イソメラーゼの反応機構

概要

論文の詳細を見る
Isopentenyl diphosphate and dimethylallyl diphosphate are known as active isoprene units for the biosynthesis of isoprenoids, the most diverse family of natural compounds containing >55,000 identified members. Isomerization between the two essential compounds for isoprenoid biosynthesis is catalyzed by isopentenyl diphosphate isomerase, and two types of the enzyme with no sequential homology have been found. Although the reaction mechanism of type 1 enzyme has been studied in detail, that of type 2 isopentenyl diphosphate isomerase, which curiously requires FMN and NAD(P)H for activity, is still unclear. The importance of isopentenyl diphosphate isomerase in isoprenoid metabolism, the biological distribution of the two types of enzymes, and the-state-of-the-art studies on the reaction mechanism of type 2 enzyme were introduced in this review.
日本ビタミン学会の論文
2008-11-25