へパリン・プロスタグランジンI_2内包ヒドロゲルを担持した抗血栓性ポリエーテルウレタンウレア

概要

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Polyetherurethaneurea (PEUU) with heparin and/or prostaglandin I2 (PGI_2) immobilized on crosslinked polyacrylamide hydrogels were prepared by the addition of dry hydrogels to a PEUU dimethylformamide solution. Tensile strength of the PEUU film was not weakened very much by the addition of the hydrogels. Immobilized heparin was found to be continuously released from the PEUU matrix at 37℃ in a physiological saline. Antithrombogenic activity of PEUU with heparin and/or PGI_2 was evaluated by activated partial thromboplastin time (aPTT), whole blood clotting time, and inhibition of platelet aggregation. The heparin-immobilized PEUU exhibited excellent anticoagulant activity and the PGI_2-immobilized PEUU completely inhibit platelet aggregation of human blood after sitting for at least 72 h in a physiological saline.