H. M. Frost's Legacy: The Utah Paradigm of Skeletal Physiology

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概要

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• The still-evolving Utah Paradigm of Skeletal Physiology with its key components, the mechanostat, inserts tissue-level realities into the knowledge gap between organ-level and cell-level realities. It concerns load-bearing bones in postnatal bony vertebrates and how bones adapt their strength to mechanical loads on them. The paradigm involves the neuromuscular system, the mechanostat and their interactions with local and systemic non-mechanical agents. The mechanostat contains the genetically determined minimum effective strain general biomechanical relationship (MES_r < E < MES_m << MES_p << FX), set points, remodeling and modeling highways and feedback loops. Local and systemic non-mechanical agents can be permissive, mediate and modulate the strain-dependent signals or act directly on cellular parts of the mechanostat but cannot replace or duplicate the mechanical control. Raising the MES remodeling set point coupled with the direct effect on osteoblasts and osteoclasts can be responsible for the mechanism of action of a typical anti-catabolic agent. Lowering the MES modeling and remodeling set points along with direct stimulation of osteoblastic lineage cells can be responsible for the mechanism of action of a typical anabolic agents. All students of in vivo skeletal biology should have an understanding of the Utah paradigm of skeletal physiology. Insights into the paradigm can help to minimize serious errors in experimental designs and in interpreting data. Lastly, please remember it took decades for Harold M. Frost to develop, understand and find effective ways to explain the Utah paradigm of skeletal physiology. It is still evolving and needs improvement.

• 新潟医療福祉大学の論文

著者

• Jee Webster

  Division Of Radiobiology University Of Utah School Of Medicine

• Jee Webster

  Division Of Radiobiology University Of Utah

• Jee Webster

  Division Of Radiobiology Department Of Radiology University Of Utah School Of Medicine

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