Anti-diabetic Properties of Chrysophanol and Its Glucoside from Rhubarb Rhizome(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
An ethanol extract of rhubarb rhizome exhibited marked glucose transport activity in differentiated L6 rat myotubes. Activity-guided fractionation resulted in the isolation of two anthraquinones, chrysophanol-8-O-β-D-glucopyranoside (1) and chrysophanol (2). The anti-diabetic effect was examined by glucose transport activity, glucose transporter 4 (Glut4) expression in myotubes, and the level of insulin receptor (IR) tyrosine phosphorylation as influenced by tyrosine phosphatase 1B, each of which is a major target of diabetes treatment. Chrysophanol-8-O-β-D-glucopyranoside up to 25μM dose-dependently activated glucose transport in insulin-stimulated myotubes. Increased tyrosine phosphorylation of IR due to tyrosine phosphatase 1B inhibitory activity with an IC_<50> value of 18.34±0.29μM and unchanged Glut4 mRNA levels was observed following chrysophanol-8-O-β-D-glucopyranoside treatment. Chrysophanol up to 100μM exerted mild glucose transport activity and elevated the tyrosine phosphorylation of IR via tyrosine phosphatase 1B inhibition (IC_<50>=79.86±0.12μM); Glut4 mRNA expression was also significantly increased by 100μM. The ED_<50> values of the two compounds were 59.38±0.66 and 79.69±0.03μM, respectively. Therefore, these two anthraquinones from rhubarb rhizome, chrysophanol-8-O-β-D-glucopyranoside and chrysophanol, have mild cytotoxicity and anti-diabetic properties and could play metabolic roles in the insulin-stimulated glucose transport pathway.
- 公益社団法人日本薬学会の論文
- 2008-11-01
著者
-
Lee Hyun
Regional Cancer Inst. Chungnam National Univ. Hospital
-
Lee Myung
Department Of Family Medicine Brain Korea 21 Project Medical Science College Of Medicine Korea Unive
-
Sohn Cheon
Department Of Food And Nutrition Chungnam National University
-
Lee Myung
Department Of Electronic Engineering Kyung-hee University
関連論文
- Optical Identification of 15μm Sources in the AKARI Performance Verification Field toward the North Ecliptic Pole
- AKARI Detection of the Infrared-Bright Supernova Remnant B0104-72.3 in the Small Magellanic Cloud
- Supernova Remnants in the AKARI IRC Survey of the Large Magellanic Cloud
- Genistein-Derivatives from Tetracera scandens Stimulate Glucose-Uptake in L6 Myotubes(Pharmacognosy)
- Screening of Interleukin-2 Production inhibitor with Mouse Thymoma EL4 Cells
- Fatty Acid Synthase Inhibition by Amentoflavone Induces Apoptosis and Antiproliferation in Human Breast Cancer Cells
- The clinical impact of ^F-FDG PET in papillary thyroid carcinoma with a negative ^I whole body scan : a single-center study of 108 patients
- Correlation between serum CEA level and metabolic volume as determined by FDG PET in postoperative patients with recurrent colorectal cancer
- Regulation of Adiponectin Receptor 2 Expression via PPAR-α in NIT-1 Cells
- Topogenic Effect of Positively Charged N-terminal Amino Acid in ER Translocation of Yeast α-Factor Precursor
- Cancer screening using ^F-FDG PET/CT in Korean asymptomatic volunteers : a preliminary report
- Maximal safe dose of I-131 after failure of standard fixed dose therapy in patients with differentiated thyroid carcinoma
- Comparison of FDG-PET findings of brain metastasis from non-small-cell lung cancer and small-cell lung cancer
- Superiority of HMPAO Ictal SPECT to ECD Ictal SPECT in Localizing the Epileptogenic Zone
- Diagnostic Performance of [^F]FDG-PET and Ictal [^Tc]-HMPAO SPECT in Occipital Lobe Epilepsy
- The effect of tumor size on F-18-labeled fluorodeoxyglucose and fluoroerythronitroimidazole uptake in a murine sarcoma model
- Bone Scan Appearance of Renal Osteodystrophy in Diabetic Chronic Renal Failure Patients
- Electro-Mechanical Properties of Metal-Insulator-Metal Device Fabricated on Polymer Substrate Using Low-Temperature Process
- Evidence of Neuromuscular Adaptation According to Motor Sequential Learning in the Serial Reaction Time Task
- Effect of Washing and Subsequent Heat Treatment on Surface Characteristic of Glass Fabric Treated with Fluorocarbon Resin
- Liquid Ammonia Treatment of Lyocell
- Two Uterine Arterial Management Methods in Laparoscopic Hysterectomy
- Prediction of the ability of clozapine to treat negative symptoms from plasma glycine and serine levels in schizophrenia
- Alternative Splicing of Type II Procollagen Gene in the Dedifferentiation of Rat Epiphyseal Chondrocytes Serially Cultured in Monolayer
- Micromachining of Multilayer Thin Films for High-Speed Humidity Sensor Fabrication
- Gene Expression Profile in the Anterior Regeneration of the Earthworm Using Expressed Sequence Tags
- The Experience of Children's Asthma Camp in Korea
- Anti-diabetic Properties of Chrysophanol and Its Glucoside from Rhubarb Rhizome(Pharmacognosy)
- Texture Modification by Addition of Ca in Mg-Zn-Y Alloy