Spectroscopic, Thermal and Biological Studies of the Coordination Compounds of Sulfasalazine Drug : Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) Transition Metal Complexes

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概要

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• The complexations of sulfasalazine (H_3Suz) with some of transition metals have been investigated. Three types of complexes, [Mn(HSuz)^<-2>(H_2O)_4]・2H_2O, [M(HSuz)^<-2>(H_2O)_2]・xH_2O (M=Hg(II), ZrO(II) and VO(II), x=4,8 and 6, respectively) and [M(HSuz)^<-2>(Cl) (H_2O)_3]・xH_2O (M=Cr(III) and Y (III), x=5 and 6, respectively) were obtained and characterized by physicochemical and spectroscopic methods. The IR spectra of the complexes suggest that the H_3Suz behaves as a bidentate ligand. The tbermal decomposition of the complexes as well as thermodynamic parameters(ΔE^*, ΔH^*, ΔS^* and ΔG^*) were estimated using Coats-Redfern and Horowitz-Metzger equations. In vitro antimicrobial activities of the H_3Suz and the complexes were tested.

• 公益社団法人日本薬学会の論文
• 2008-11-01

著者

• Abd El-wahed

  Department Of Chemistry Faculty Of Science Zagazig University

• REFAT Moamen

  Department of Chemistry, Faculty of Science, Port Said, Suez Canal University

• EL-MEGHARBEL Samy

  Department of Chemistry, Faculty of Science, Zagazig University

• Refat Moamen

  Department Of Chemistry Faculty Of Science Port Said Suez Canal University

• El-megharbel Samy

  Department Of Chemistry Faculty Of Science Zagazig University

関連論文

• Spectroscopic, Thermal and Biological Studies of the Coordination Compounds of Sulfasalazine Drug : Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) Transition Metal Complexes

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