The Relation Between Adiponectin and four Hypercoagulable, Inflammatory Biomarkers During Normal Pregnancy
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概要
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Eendothelial dysfunction may not occur, even though the hemostatic balance is displaced toward hypercoagulability during pregnancy with enhanced inflammation. Also adiponectin, an adipose tissue-specific plasma protein, was recently revealed to have anti-inflammatory effects on the cellular components of the vascular wall. However, it is still unclear whether or not plasma adiponectin concentrations change during normal pregnancy. Despite a lot of research on the physiological adaptation to pregnancy, relatively little is known about the biological adaptation in the hemostatic, inflammatory changes and endothelial damage. To evaluate the relationship between various biomarkers for endothelial damage and the hypercoagulable, inflammatory state during pregnancy, five biomarkers, namely plasma adiponectin, soluble thrombomodulin (sTM), interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and thrombin-antithrombin complex (TAT) were measured in 15 nonpregnant healthy women, 60 pregnant women (namely 10th, 20th, 30th, and 38th week of gestation) and 15 postpartum women. The present study revealed that during pregnancy the plasma adiponectin concentrations were increased, while the concentrations of sTM and TNF-alpha did not change and those of TAT and IL-6 were elevated. Elevating the adiponectin concentrations, diminishing endothelial damage and leading to an antithrombotic and anti-inflammatory environment may be beneficial during pregnancy.
- 獨協医科大学の論文