Cytotoxic and Anti-oxidant Activities of Lanostane-Type Triterpenes Isolated from Poria cocos
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概要
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A new lanostane-type triterpene, 29-hydroxypolyporenic acid C (8), was isolated from the dried sclerotia of Poria cocos together with eight other known compounds pachymic acid (1), dehydropachymic acid (2), 3-acetyloxy-16α-hydroxytrametenolic acid (3), polyporenic acid C (4), 3-epi-dehydropachymic acid (5),3-epi-dehydrotumulosic acid (6), tumulosic acid (7), and dehydrotumulosic acid (9). The compounds were identified by spectral analysis and comparison with spectroscopic data reported in the literatures. Although none of the nine (1 to 9) compounds showed promising antioxidant activity, 1 through 6 and 8 showed good cytotoxicity against human lung cancer cell line A549 and human prostate cancer cell line DU145. Interestingly, all these compounds exhibited better cytotoxicity towards A549 than DU145 cells.
- 2008-10-01
著者
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NG Ka-yun
Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center
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Ng Ka-yun
Department Of Pharmaceutical Sciences University Of Colorado Health Sciences Center
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Ng Ka-yun
Department Of Pharmacy National University Of Singapore
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Gapter Leslie
Department Of Pharmacy National University Of Singapore
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Zhou Liang
Department Of Chemistry And Shanghai Key Laboratory Of Molecular Catalysis And Innovative Materials
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Zhou Liang
Department Of Pharmacy National University Of Singapore
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ZHANG Yaochun
Department of Pharmacy, National University of Singapore
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LING Hui
Department of Pharmacy, National University of Singapore
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AGARWAL Rajesh
Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado at Denver and Heal
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Ling Hui
Department Of Pharmacy National University Of Singapore
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Zhang Yaochun
Department Of Pharmacy National University Of Singapore
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Agarwal Rajesh
Department Of Pharmaceutical Sciences School Of Pharmacy University Of Colorado At Denver And Health
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Ling Hui
Department Of Experimental Therapeutics The University Of Texas Md Anderson Cancer Center
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