New Organoselenium Compounds Active against Pathogenic Bacteria, Fungi and Viruses
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概要
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Different N-substituted benzisoselenazol-3 (2H)-ones, analogues of ebselen were designed as new antiviral and antimicrobial agents. We report their synthesis, chemical properties as well as study on biological activity against broad spectrum of pathogenic microorganisms (Staphylococcus aureus, Staphylococcus simulans, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Aspergillus niger) and viruses (herpes simplex virus type 1 (HSV-1), encephalomyocarditis virus (EMCV), vesicular stomatitis virus (VSV)), in vitro. Most of them exhibited high activity against viruses (HSV-1, EMCV) and gram-positive bacteria strains (S. aureus, S. simulans), while their activity against gram-negative bacteria strains (E. coli, P. aeruginosa, K. pneumoniae) was substantially lower. Some of tested compounds were active against yeast C. albicans and filamentous fungus A. niger.
- 2008-10-01
著者
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Wojtowicz(mlochowska) Halina
Department Of Organic Chemistry Faculty Of Chemistry Wroclaw University Of Technology
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PIETKA(OTTLIK) Magdalena
Department of Organic Chemistry, Faculty of Chemistry, Wroclaw University of Technology
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KOLODZIEJCZYK Katarzyna
Department of Organic Chemistry, Faculty of Chemistry, Wroclaw University of Technology
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PIASECKI Egbert
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
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MLOCHOWSKI Jacek
Department of Organic Chemistry, Faculty of Chemistry, Wroclaw University of Technology
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Piasecki Egbert
Institute Of Immunology And Experimental Therapy Polish Academy Of Sciences
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Mlochowski Jacek
Department Of Organic Chemistry Faculty Of Chemistry Wroclaw University Of Technology
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Kolodziejczyk Katarzyna
Department Of Organic Chemistry Faculty Of Chemistry Wroclaw University Of Technology
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Pietka(ottlik) Magdalena
Department Of Organic Chemistry Faculty Of Chemistry Wroclaw University Of Technology
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Pietka-Ottlik Magdalena
Department of Organic Chemistry, Faculty of Chemistry, Wroclaw University of Technology
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Wojtowicz-Mlochowska Halina
Department of Organic Chemistry, Faculty of Chemistry, Wroclaw University of Technology
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