The Effect of Amiodarone on K^+ Channel Current in the Normal and Hypertrophied Rat Heart

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概要

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• The basis for the unique effectiveness of amiodarone treatment on cardiac arrhythmias is incompletely understood. We investigated and compared the effects of amiodarone on K^+ channels of hypertrophied ventricular myocytes with normal ventricular myocytes in rats. The pressure overload hypertrophy models of rats were established by partial ligation of ascending aorta for 4 weeks. Ventricular myocytes were exposed to 1, 10 and 50μmol/l amiodarone, and whole cell patch-clamp technique was used to study the effects of amiodarone on outward currents, such as delayed rectifier outward K^+ current (I_K), slowly activating delayed rectifier outward K^+ current (I_<Ks>), transient outward K^+ current (I_<to>) and rectifier K^+ current (I_<K1>). Compared with the control group, the current density of I_K, I_<K1> and I_to were all decreased in hypertrophied myocytes group. Hyper-concentration of amiodarone (10 and 50μmol/l) inhibited I_to of the control group (37.5%±5.8% and 54.3%±5.7%) and the hypertrophied myocytes group (9.3%±2.3% and 22.8%±3.0%), but had effect on I_<K1> neither the control nor hypertrophied myocytes group. 10μmol/l amiodarone inhibited I_<Ks> 23.3%±6.2%in the control group and 50.1%±9.8% in the hypertrophied myocytes group. I_<to> and I_<Ks> appeared difference affection of amiodarone's action on both groups. I_<Ks> in hypertrophy group was higher than that in control, whereas I_<to> was lower in hypertrophy group. We concluded amiodarone do inhibit I_<to> and I_K in rat normal and hypertrophied cardiomyocytes. Amiodarone application should be treated difference between hypertrophied heart and normal heart.

• 2008-10-01

著者

• Wei Yidong

  Department Of Cardiology Shanghai Tenth People's Hospital Tongji University

• Wei Jinghan

  Department Of Cardiology The First Affiliated Hospital Of Zhengzhou University

• Wei Jinghan

  Department Of Cardiology First Affiliated Hospital Of Zhengzhou University

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