Variants in the Nestin Gene and Coronary Heart Disease

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概要

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• Background The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. Methods and Results The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs 11582300 and rs 3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Conclusion Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required.

• 社団法人日本循環器学会の論文
• 2008-08-20

著者

• Mckeown Pascal

  Regional Medical Cardiology Centre Royal Victoria Hospital

• Hughes Anne

  Department Of Cardiothoracic Surgery St. James's Hospital

• Hughes Anne

  Department Of Medical Genetics Queen's University Belfast

• Patterson Chris

  Department Of Epidemiology And Public Health Queen's University Belfast

• Meng Weihua

  Department of Medicine, Institute of Clinical Science, Queen's University Belfast

• Belton Christine

  Department of Medicine, Institute of Clinical Science, Queen's University Belfast

• Belton Christine

  Department Of Medicine Institute Of Clinical Science Queen's University Belfast

• Meng Weihua

  Department Of Medicine Institute Of Clinical Science Queen's University Belfast

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• Variants in the Nestin Gene and Coronary Heart Disease

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