Spontaneous Conformational Fluctuations in Cell Signaling Proteins of Ras(WHAT IS LIFE? THE NEXT 100 YEARS OF YUKAWA'S DREAM)
スポンサーリンク
概要
- 論文の詳細を見る
Spontaneous conformational fluctuations in protein molecules have been recently studied by single molecule detection techniques. In this paper, we report the dynamical conformational fluctuations of Ras, a key protein that regulates various cell signaling dynamics, by using single molecule fluorescence resonance energy transfer. Ras was found to be dynamic, spontaneously taking several multiple meta-stable states and fluctuating between them in the order of msec to sec. The states, however, converged to one specific conformation in the presence of effector molecules. The spontaneous fluctuations allow for the dynamic response to multiple effectors.
- 理論物理学刊行会の論文
- 2008-08-08
著者
-
Ishii Yoshiharu
Formation Of Soft Nano-machines Crest
-
Yanagida Toshio
Soft Biosystem Group Laboratories For Nanobiology Graduate School Of Frontier Biosciences University
-
IWANE Atsuko
Soft Biosystems Group, Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University
-
YANAGIDA Toshio
Soft Biosystems Group, Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University:Formation of Soft Nanomachines, Core Research for Evolution Science and Technology, Japan Science and Technology Agency
-
Arai Yoshiyuki
Soft Biosystems Group, Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University
関連論文
- 1P532 Simultaneous observation of rotatory and stepping motions of single myosin II molecules(26. Single molecule biophysics,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- 2P013 Multiple conformational changes of Ras observed by single molecule FRET(29. Protein structure and dynamics (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- 1P273 Cooperativity causes plasticity in molecular motors(9. Molecular motor (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- 1P285 The mode of interaction between myosin V and actin filament(9. Molecular motor (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- Spontaneous Conformational Fluctuations in Cell Signaling Proteins of Ras(WHAT IS LIFE? THE NEXT 100 YEARS OF YUKAWA'S DREAM)