Study on the mechanism of insecticidal activity through disruption of intracellular calcium homeostasis(Society Award 2008 (on high prospectiveness))

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概要

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• Flubendiamide is a new compound developed as an insecticide with potent activity against lepidopterous pests. The present study demonstrated that the compound possessed insecticidal activity through a specific effect on intracellular Ca^<2+> kinetics, which was signified by pronounced Ca^<2+> pump stimulation. Further study clarified that the compound intrinsically activated the ryanodine-sensitive calcium release channel (ryanodine receptors, RyRs). The results of this study indicated that insect RyR is a promising target molecule for a new insecticide with high selectivity and low toxicity to mammals.

• 日本農薬学会の論文
• 2008-08-20

著者

• Masaki Takao

  Research Center Nihon Nohyaku Co. Ltd. R&d Strategy Department Research & Development Divisi

関連論文

• Study on the mechanism of insecticidal activity through disruption of intracellular calcium homeostasis(Society Award 2008 (on high prospectiveness))

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