Reduction of Mitochondrial Oxidative Damage and Improved Mitochondrial Efficiency by Administration of Crocetin against Benzo[a]pyrene Induced Experimental Animals(Analytical Biochemistry)
スポンサーリンク
概要
- 論文の詳細を見る
The mitochondrial damage in the lung was assessed by examining the levels of reactive oxygen species (ROS), lipid peroxides, reduced glutathione, and the activities of isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, complexes I to IV, and cytochrome c. The oxidative phosphorylation (levels of adenosine triphosphatase) was evaluated for the assessment of mitochondrial functional capacity. We found significantly elevated levels of ROS, lipid peroxides, and decreased levels of mitochondria) enzymes in the mice administered with benzo[a]pyrene (B[a]p). Measurement of oxidative phosphorylation revealed a marked depletion in all the variables studied. Administration of crocetin prevented the structural and functional impairment of mitochondria upon administration to B[a]p. From the results, we suggest that administration of B[a]p induces damage to the lung mitochondria and crocetin protects the lung from damage by maintaining the structural and functional integrity of the mitochondrial membrane.
- 公益社団法人日本薬学会の論文
- 2008-09-01
著者
-
Dhanapal Sakthisekaran
Department Of Medical Biochemistry Dr. A.l.m.p.g. Institute Of Basic Medical Sciences University Of
-
Dhanapal Sakthisekaran
Department Of Medical Biochemistry Dr. A L Mudaliar Post Graduate Institute Of Basic Medical Science
-
Ganapathy Ekambaram
Department Of Medical Biochemistry Dr. A.l.m.p.g. Institute Of Basic Medical Sciences University Of
-
Peramaiyan Rajendran
Department Of Medical Biochemistry Dr. A.l.m.p.g. Institute Of Basic Medical Sciences University Of
-
VENKATRAMAN Magesh
Department of Medical Biochemistry, Dr. A.L.M.P.G. Institute of Basic Medical Sciences, University o
-
KONGA Durgabhavani
Department of Pharmacology and Environmental Toxicology, Dr. A.L.M.P.G. Institute of Basic Medical S
-
Venkatraman Magesh
Department Of Medical Biochemistry Dr. A.l.m.p.g. Institute Of Basic Medical Sciences University Of
-
Konga Durgabhavani
Department Of Pharmacology And Environmental Toxicology Dr. A.l.m.p.g. Institute Of Basic Medical Sc
関連論文
- Effect of Genistein on Modulating Lipid Peroxidation and Membrane-bound Enzymes in N-Nitrosodiethylamine-induced and Phenobarbital-promoted Rat Liver Carcinogenesis
- Dysfunctional High-Density Lipoprotein and the Potential of Apolipoprotein A-1 Mimetic Peptides to Normalize the Composition and Function of Lipoproteins
- Reduction of Mitochondrial Oxidative Damage and Improved Mitochondrial Efficiency by Administration of Crocetin against Benzo[a]pyrene Induced Experimental Animals(Analytical Biochemistry)