外見上健康なヒトドナー由来日和見病原体Klebsiella pneumoniaeにより引き起こされたヒト糞便菌叢接種子ブタにおける致死的感染(実験動物学)
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概要
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外見上健康なヒトドナーの糞便菌叢を経口投与された24匹のhuman flora-associated (HFA)子ブタのうち17匹が死亡した.感染した子ブタの器官から分離された細菌は,細菌学的及び生化学的テスト,更には16SrRNAの塩基配列解析よりKlebsiella pneumoniaeと同定された.同一のK. pneumoniae株がドナーの糞便菌叢より分離された.ドナーから分離したK. pneumoniaeを接種された3匹の新生ブタはすべて重篤な下痢を呈し,そのうちの2匹は死亡した.このことはヒトドナー由来の日和見病原体であるK. pneumoniaeがHFA子ブタに対しては致死的感染をもたらすことを強く示唆している.この結果はHFA子ブタを作出する際に用いるヒトドナー糞便の安全性評価の重要性を喚起している.
- 社団法人日本獣医学会の論文
- 2008-07-25
著者
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ZHANG Yan
Laboratory of MRAMP of China
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CUI Li
Department of Pediatric Surgery, Osaka University Medical School
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Cui Li
Department Of Anatomy And Organ Technology Shinshu University School Of Medicine
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Cui Li
Department Of Animal Science College Of Agriculture And Biology Shanghai Jiao Tong University
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WEI Hua
Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Bioscience and Biotechnolog
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SHEN Jian
Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Bioscience and Biotechnolog
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PANG Xiaoyan
Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Bioscience and Biotechnolog
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DING Dezhong
Department of Animal Science, College of Agriculture and Biology, Shanghai Jiao Tong University
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ZHANG Baorang
Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Bioscience and Biotechnolog
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LU Haifeng
Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Bioscience and Biotechnolog
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WANG Tingting
Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Bioscience and Biotechnolog
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ZHANG Chenhong
Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Bioscience and Biotechnolog
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HUA Xiuguo
Department of Animal Science, College of Agriculture and Biology, Shanghai Jiao Tong University
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ZHAO Liping
Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Bioscience and Biotechnolog
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Shen Jian
Laboratory Of Molecular Microbial Ecology And Ecogenomics Department Of Bioscience And Biotechnology
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Lu Haifeng
Laboratory Of Molecular Microbial Ecology And Ecogenomics Department Of Bioscience And Biotechnology
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Hua Xiuguo
Department Of Animal Science College Of Agriculture And Biology Shanghai Jiao Tong University
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Zhao Liping
Laboratory Of Molecular Microbial Ecology And Ecogenomics Department Of Bioscience And Biotechnology
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Ding Dezhong
Department Of Animal Science College Of Agriculture And Biology Shanghai Jiao Tong University
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Pang Xiaoyan
Laboratory Of Molecular Microbial Ecology And Ecogenomics Department Of Bioscience And Biotechnology
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Zhang Baorang
Laboratory Of Molecular Microbial Ecology And Ecogenomics Department Of Bioscience And Biotechnology
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Wang Tingting
Laboratory Of Molecular Microbial Ecology And Ecogenomics Department Of Bioscience And Biotechnology
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Zhang Chenhong
Laboratory Of Molecular Microbial Ecology And Ecogenomics Department Of Bioscience And Biotechnology
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Wei Hua
Laboratory Of Molecular Microbial Ecology And Ecogenomics Department Of Bioscience And Biotechnology
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Zhang Yan
Laboratory Of Molecular Microbial Ecology And Ecogenomics Department Of Bioscience And Biotechnology
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Zhang Yan
Laboratory Of Biomechanics School Of Medicine Shanghai Jiao Tong University
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