Dexamethasone Inhibits Leukocyte Accumulation and Vascular Permeability in Retina of Streptozotocin-Induced Diabetic Rats via Reducing Vascular Endothelial Growth Factor and Intercellular Adhesion Molecule-1 Expression(Pharmacology)
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概要
- 論文の詳細を見る
Intravitreal injection of corticosteroid has been-used to treat diabetic macular edema, however, the exact mechanism remains unknown. In the present experiment, four weeks after streptozotocin administration, intravitreal injection of dexamethasone (50 μg/10μl) was performed. After 2d injection, we investigated the effect of dexamethasone on leukocyte accumulation, vascular permeability and the expression of vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1) in streptozotocin-diabetic rats. Accumulated leukocytes were counted in vivo by acridine orange leukocyte fluorography, the retinal vascular permeability was measured by the Evans blue assay. The mRNA and protein level of VEGF and ICAM-1 were analyzed with real-time quantitative polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) respectively. Dexamethasone downregulated VEGF and ICAM-1 expression in diabetic rats which correlated with its effect on leukocytes accumulation and retinal vascular permeability. The present data revealed that dexamethasone may inhibit retinal accumulation and leukostasis accumulation and vascular permeability through its blockage on VEGF and ICAM-1 expression.
- 公益社団法人日本薬学会の論文
- 2008-08-01
著者
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Li Xinmin
Department Of Ophthalmology Beijing Capital Medical University Affiliated Beijing Friendship Hospita
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WANG Kang
Department of Electrical Engineering, University of California
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Wang Kang
Department Of Ophthalmology Beijing Capital Medical University Affiliated Beijing Friendship Hospita
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Wang Kang
Department Of Electrical Engineering University Of California
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WANG Yanling
Department of Ophthalmology, Beijing Capital Medical University Affiliated Beijing Friendship Hospit
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GAO Lixin
Department of Ophthalmology, Beijing Capital Medical University Affiliated Beijing Friendship Hospit
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LI Mingming
Department of Ophthalmology, Beijing Capital Medical University Affiliated Beijing Friendship Hospit
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GUO Jianyou
Key Laboratory of Mental Healthy, Institute of Psychology, Chinese Academy of Sciences
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Gao Lixin
Department Of Ophthalmology Beijing Capital Medical University Affiliated Beijing Friendship Hospita
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Li Mingming
Department Of Ophthalmology Beijing Capital Medical University Affiliated Beijing Friendship Hospita
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Guo Jianyou
Key Laboratory Of Mental Healthy Institute Of Psychology Chinese Academy Of Sciences
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Wang Yanling
Department Of Ophthalmology Beijing Capital Medical University Affiliated Beijing Friendship Hospita
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