Fine Synthetic Nucleoside Chemistry Based on Nucleoside Natural Products Synthesis

スポンサーリンク

概要

• 論文の詳細を見る

• Synthetic nucleoside chemistry based on nucleoside natural products synthesis were described. First, a samarium diiodide (SmI_2)-promoted aldol reaction with the use of α-phenylthioketone as an enolate was developed. The characteristics of this reaction are that the enolate can be regioselectively generated and the aldol reaction proceeds under near neutral condition. This reaction is proved to be a powerful reaction for the synthesis of complex nucleoside natural products, and herbicidin B and fully protected tunicaminyluracil, which were undecose nucleoside natural products, were synthesized. Next, the synthetic methodology of the caprazamycins, which are promising antibacterial nucleoside natural products, was also developed by the strategy including β-selective ribosylation without using a neighboring group participation. Our synthetic route provided a range of key analogues with partial structures to define the pharmacophore. Simplification of the caprazamycins was further pursued to develop diketopiperazine analogs.

• 2008-08-01

著者

• Ichikawa Satoshi

  Graduate School Of Engineering Kyoto University

関連論文

• P-530 Synthetic Study of the Stable Analog of Chitin Synthase Inhibitors, Guanofosfosins
• A Systematic Numerical Method to Analyze Hybrid Networks Composed of Linear/Nonlinear Lumped Elements and Transmission Lines with Distributed Sources
• Fine Synthetic Nucleoside Chemistry Based on Nucleoside Natural Products Synthesis
• 3PS015 原子間力顕微鏡を用いた単一細胞レオロジーの高速・精密測定法の開発(日本生物物理学会第50回年会(2012年度))

スポンサーリンク